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Hormônio do crescimento ou somatotrófico: novas perspectivas na deficiência isolada de GH a partir da descrição da mutação no gene do receptor do GHRH nos indivíduos da cidade de Itabaianinha, Brasil

2004; Editora da Universidade de São Paulo; Volume: 48; Issue: 3 Linguagem: Inglês

10.1590/s0004-27302004000300013

1677-9487

Anita H. O. Souza, Roberto Salvatori, Carlos Eduardo Martinelli, Walter M.O. Carvalho, Carlos Alberto Menezes, Elenilde S. De A. Barretto, José Augusto Soares Barreto-Filho, Marta Regina Silva Alcântara, Carla R. P. Oliveira, Paula Regina Silva Alcântara, Roberto J. R. Ramalho, Hélio Araújo Oliveira, I.B. Lima, Jamille N. Carneiro, Marcos M. Santos, Matthew S. Gill, Peter Clayton, Matheus Henrique Santos Lira Oliveira,

Growth Hormone and Insulin-like Growth Factors

In addition to stimulating body growth, growth or somatotrophic hormone plays an important role in metabolism, body composition, lipid profile, cardiovascular status and longevity. Its control is multiregulated by hormones, metabolites and hypothalamic peptides. Obtained data of the isolated growth hormone deficiency (IGHD) after the description of the IVS1+1G-->A GHRH receptor gene mutation in individuals of Itabaianinha County are reviewed. New perspectives about the growth hormone resistance model, the importance of GHRH in the control of GH secretion, the frequency of GHRH-R gene mutations, the diagnostic relevance of IGF-I and the metabolic, cardiovascular and quality of life findings are approached.