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Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion?

2013; Dove Medical Press; Linguagem: Inglês

10.2147/ott.s38520

1178-6930

Antonin Lévy, Gazzah, Daniel Barrios Gonzalez, Bahleda, Ducreux, Lacroix, Soria,

Cancer Genomics and Diagnostics

Despite a modern validated regimen of chemotherapy, advanced pancreatic adenocarcinoma remains the fourth most common cause of cancer-related death worldwide. The phosphoinositide 3-kinase pathway (PI3K)/Akt/mammalian target of rapamycin (mTOR) is a major signaling pathway that may be activated in advanced pancreatic cancer. To highlight the potential interest of this targetable pathway in selected advanced pancreatic cancer patients, we report herein a patient with an activated PI3K mutation who was treated in a phase I trial evaluating a treatment combination including an mTOR inhibitor.