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Fiberoptic endoscopic examination and biopsy in determining the extent of nasopharyngeal carcinoma

1989; Wiley; Volume: 64; Issue: 9 Linguagem: Inglês

10.1002/1097-0142(19891101)64

1097-0142

Jonathan S.T. Sham, WI Wei, W. H. Kwan, C. W. Chan, Peter H.K. Choi, D. Choy,

Head and Neck Surgical Oncology

CancerVolume 64, Issue 9 p. 1838-1842 ArticleFree Access Fiberoptic endoscopic examination and biopsy in determining the extent of nasopharyngeal carcinoma Jonathan S. T. Sham MB, BS, DMRT, FRCR, Corresponding Author Jonathan S. T. Sham MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongDepartment of Radiotherapy and Oncology, Queen Mary Hospital, Pokfulam, Hong Kong===Search for more papers by this authorW. I. Wei MB, BS, DLO, FRCS(Edin), FACS, W. I. Wei MB, BS, DLO, FRCS(Edin), FACS Department of Surgery, University of Hong Kong; Queen Mary Hospital, Hong KongSearch for more papers by this authorW. H. Kwan MB, BS, DMRT, FRCR, W. H. Kwan MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongSearch for more papers by this authorC. W. Chan MB, BS, FRCPath, FRCPA, C. W. Chan MB, BS, FRCPath, FRCPA Department of Pathology, University of Hong Kong; Queen Mary Hospital, Hong KongSearch for more papers by this authorP. H. K. Choi MB, BS, DMRT, FRCR, P. H. K. Choi MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongSearch for more papers by this authorD. Choy MB, BS, DMRT, FRCR, D. Choy MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongSearch for more papers by this author Jonathan S. T. Sham MB, BS, DMRT, FRCR, Corresponding Author Jonathan S. T. Sham MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongDepartment of Radiotherapy and Oncology, Queen Mary Hospital, Pokfulam, Hong Kong===Search for more papers by this authorW. I. Wei MB, BS, DLO, FRCS(Edin), FACS, W. I. Wei MB, BS, DLO, FRCS(Edin), FACS Department of Surgery, University of Hong Kong; Queen Mary Hospital, Hong KongSearch for more papers by this authorW. H. Kwan MB, BS, DMRT, FRCR, W. H. Kwan MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongSearch for more papers by this authorC. W. Chan MB, BS, FRCPath, FRCPA, C. W. Chan MB, BS, FRCPath, FRCPA Department of Pathology, University of Hong Kong; Queen Mary Hospital, Hong KongSearch for more papers by this authorP. H. K. Choi MB, BS, DMRT, FRCR, P. H. K. Choi MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongSearch for more papers by this authorD. Choy MB, BS, DMRT, FRCR, D. Choy MB, BS, DMRT, FRCR Department of Radiotherapy and Oncology, Queen Mary Hospital, Hong KongSearch for more papers by this author First published: 1 November 1989 https://doi.org/10.1002/1097-0142(19891101)64:9 3.0.CO;2-CCitations: 42AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract This is a prospective study on the use of flexible endoscope and multiple biopsies in the assessment of nasopharyngeal carcinoma in 72 patients. This study confirmed the presence of submucosal growth pattern in nasopharyngeal carcinoma and this occurred in 13.8% of patients. Occult microscopic extension of tumor not detectable by fiberoptic endoscopy occurred in another 51.4% of patients. It has also been shown that multiple biopsy is superior to clinical examination in evaluating the extent of disease in nasopharyngeal carcinoma. Multiple biopsies are suggested for the early detection of nasopharyngeal carcinoma in high-risk cases. Although the better-defined tumor extent do not currently influence the treatment policy of nasopharyngeal carcinoma, and it is too early to assess its prognostic significance, it betters our understanding of the behavior of this tumor. Future analysis in correlation with long-term follow-up data may help to improve the stage classification systems and treatment strategy. References 1 Lederman M. Cancer of the Nasopharynx: Its Natural History and Treatment. Springfield, IL: CC Thomas, 1961. 2 Wei WI, Lau WF, Lam KH, Hui Y. The role of fiberoptic bronchoscope in otorhinolaryngological practice. J Laryngol Otol 1987; 101: 1263–1270. 3 American Joint Committee on Cancer. Manual for Staging of Cancer. Philadelphia: JB Lippincott, 1988; 33–35. 4 International Union Against Cancer TMN Classification of Malignant Tumours. Springer-Verlag, 1987; 19–22. 5 Chiang TC, Jung PF. The nasopharyngoscope and camera examination of the primary carcinoma of nasopharynx. Cancer 1977; 40: 2353–2364. 6 Silberman HD. Flexible fiberoptic nasopharyngolaryngoscope. Ann Otol Rhinol Laryngol 1976; 85: 640–645. 7 del Regato JA, Spjut HJ. Respiratory system: Upper digestive tract/nasopharynx. In: JA del Regato, ed. Ackerman and del Regato's Cancer: Diagnosis, Treatment, and Prognosis, ed. 5. St. Louis: CV Mosby, 1977; 301–318. 8 Screening for nasopharyngeal carcinoma (editorial). Lancet 1984; 2 (8393): 20–22. 9 Shanmugham MS. The role of fiberoptic nasopharyngoscopy in nasopharyngeal carcinoma (NPC). J Laryngol Otol 1985; 99: 779–782. 10 Wei WI. A comparison of clinical staging systems in nasopharyngeal carcinoma. Clin Oncol 1984; 10: 225–231. 11 Ho JHC, Lau WH. Clinical staging of NPC. In: E Grundmann, GRF Krueger, DV Ablashi, eds. Cancer Campaign, vol. 5: Nasopharyngeal Carcinoma. New York: Gustav Fischer Verlag Stuttgart, 1981; 318–320. 12 Lau WH, Kwan HC, Ho JHC. Serum IgA antibodies to the viral capsid antigen (VCA) of Epstein-Barr virus as diagnostic markers in nasopharyngeal carcinoma. In: U Prasad, DV Ablashi, PH Levine et al., eds. Nasopharyngeal Carcinoma: Current Concepts. Kuala Lumpur: University of Malaysia, 1983; 125–129. 13 Ho JHC, Lau WH, Kwan HC. Diagnostic and prognostic serological markers in nasopharyngeal carcinoma (NPC). In: E Grundmann, GRF Krueger, DV Ablashi, eds. Cancer Campaign, vol. 5: Nasopharyngeal Carcinoma. New York: Gustav Fischer Verlag Stuttgart, 1981; 219–224. 14 Von Haacke NP. Screening for nasopharyngeal carcinoma (letter). Lancet 1984; 2 (8401): 528. Citing Literature Volume64, Issue91 November 1989Pages 1838-1842 ReferencesRelatedInformation