Aortic endothelial mitosis and evans blue uptake in cholesterol-fed subscorbutic guinea-pigs
1975; Elsevier BV; Volume: 21; Issue: 1 Linguagem: Inglês
10.1016/0021-9150(75)90097-0
ISSN1879-1484
AutoresH. P. Wright, Malkanthi Evans, R.P. Green,
Tópico(s)Adipokines, Inflammation, and Metabolic Diseases
ResumoGroups of ovalbumin sensitised, subscorbutic guinea-pigs were subjected to various regimens for 8–10 weeks. Group 1 were given 0.25 mg/100 g body wt. chol esterol by mouth daily and were stressed with intraperitoneal injections of ovalbumil twice weekly. Group 2 received the cholesterol only and Group 3 were stressed only. Group 4 on the low vitamin C diet only acted as controls. Evans blue uptake tests and tritiated thymidine autoradiographs of Häutchen preparations of aortic endotheliun were made on each animal. Endothelial mitosis was greatest in those areas of the aorta that had taken up the Evans blue most avidly. This was most apparent in Groul 1, though to a lesser extent in Groups 2 and 3 also. Group 4 showed no dye uptake and the mitotic index was not raised. Blood ascorbic acid and plasma cholesterol level are given for the various groups.
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