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Synthesis of 4‐protio‐3‐carbamoyl‐2,2,5,5‐tetraperdeuteromethyl‐3‐pyrrolin‐1‐yloxy (mHCTPO): A selectively isotopically labeled compound for use in T 2 spin label oxymetry

1990; Wiley; Volume: 28; Issue: 6 Linguagem: Inglês

10.1002/jlcr.2580280602

1099-1344

Yawares J. Lin, Beverly A. Teicher, Howard J. Halpern,

Nitric Oxide and Endothelin Effects

Abstract The title compound (mHCTPO) has been prepared to enhance sensitivity to molecular oxygen concentration in its Electron Spin Resonance (ESR) spectrum. The synthesis involved a novel variant of the traditional nitroxide synthesis leading to a much improved yield of mHCTPO over the several steps of the synthesis. An enhancement of T 2 spin label oxymetry with independent measurment of spin label concentration (from a spectral feature) has been observed. This molecule represents a new class of potentially valuable compounds for in vivo application and for imaging in ESR oxymetry.