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Molecular Signaling of Somatostatin Receptors

2004; Wiley; Volume: 1014; Issue: 1 Linguagem: Inglês

10.1196/annals.1294.012

1749-6632

Hicham Lahlou, Julie Guillermet‐Guibert, Marylis Hortala, Fabienne Vernejoul, Stéphane Pyronnet, Corinne Bousquet, Christiane Susini,

Neuroblastoma Research and Treatments

A bstract : Somatostatin is a neuropeptide family that is produced by neuroendocrine, inflammatory, and immune cells in response to different stimuli. Somatostatin acts as an endogenous inhibitory regulator of various cellular functions including secretions, motility, and proliferation. Its action is mediated by a family of G‐protein‐coupled receptors (called sst1‐sst5) that are widely distributed in the brain and periphery. The five receptors bind the natural peptides with high affinity, but only sst2, sst5, and sst3 bind the short synthetic analogs used to treat acromegaly and neuroendocrine tumors. This review covers the current knowledge in somatostatin receptor biology and signaling.