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A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation

2011; Royal Society of Chemistry; Volume: 47; Issue: 35 Linguagem: Inglês

10.1039/c1cc11562f

1364-548X

Jing Wang, Samantha L. H. Higgins, A. Winkel, Karen J. Brewer,

Molecular Sensors and Ion Detection

Many Ru and Os systems display photoactive (3)MLCT states. Systems activated by therapeutic window light in the absence of O(2) remain elusive. [(bpy)(2)Os(dpp)RhCl(2)(phen)](3+) photobinds and photocleaves DNA under red light in an oxygen independent manner, due to molecular design involving one Os chromophore coupled to a photoactive cis-Rh(III)Cl(2) moiety.