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Synthesis, isomerisation and diels-alder reactions of (5S)-5-phenyl-3,4-dehydromorpholin-2-one

1996; Elsevier BV; Volume: 7; Issue: 9 Linguagem: Inglês

10.1016/0957-4166(96)00329-1

1362-511X

David J. Ager, Nicholas R. Cooper, Geoffrey G. Cox, F. GARRO‐HELION, Laurence M. Harwood,

Asymmetric Synthesis and Catalysis

(5S)-5-Phenyl-3,4-dehydromorpholin-2-one [(5S)-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one] 2a is prepared by a one-pot bromination / dehydrobromination of (5S)-5-phenyl morpholin-2-one and undergoes regio- and diastereocontrolled catalysed Diels-Alder reactions.