Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam
2001; Wiley; Volume: 26; Issue: 5 Linguagem: Inglês
10.1046/j.1365-2710.2001.00367.x
ISSN1365-2710
AutoresShahin Akhondzadeh, Hamid Reza Naghavi, Mohsen Vazirian, A. Shayeganpour, Homeira Rashidi, M Khani,
Tópico(s)Attention Deficit Hyperactivity Disorder
ResumoJournal of Clinical Pharmacy and TherapeuticsVolume 26, Issue 5 p. 363-367 Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam S. Akhondzadeh PhD, S. Akhondzadeh PhD Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, Iran Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this authorH. R. Naghavi MD, H. R. Naghavi MD Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, IranSearch for more papers by this authorM. Vazirian MD, M. Vazirian MD Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, IranSearch for more papers by this authorA. Shayeganpour PharmD, A. Shayeganpour PharmD Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this authorH. Rashidi PharmD, H. Rashidi PharmD Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this authorM. Khani MSc, M. Khani MSc Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this author S. Akhondzadeh PhD, S. Akhondzadeh PhD Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, Iran Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this authorH. R. Naghavi MD, H. R. Naghavi MD Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, IranSearch for more papers by this authorM. Vazirian MD, M. Vazirian MD Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, IranSearch for more papers by this authorA. Shayeganpour PharmD, A. Shayeganpour PharmD Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this authorH. Rashidi PharmD, H. Rashidi PharmD Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this authorM. Khani MSc, M. Khani MSc Institute of Medicinal Plants, Jehad-E-Daneshgahi, Tehran, IranSearch for more papers by this author First published: 12 January 2002 https://doi.org/10.1046/j.1365-2710.2001.00367.xCitations: 150 Dr Shahin Akhondzadeh PhD No. 29, 39th Street, Gisha Street, Tehran 14479, Iran. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Objective: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder. Methods: The study was performed on 36 out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial. Results: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam. Conclusion: The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large-scale trial is justified. Citing Literature Volume26, Issue5October 2001Pages 363-367 RelatedInformation
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