Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm
1978; Elsevier BV; Volume: 27; Issue: 6 Linguagem: Inglês
10.1016/0026-0495(78)90007-0
ISSN1532-8600
AutoresNancy J. Olsen, Victor S. Fang, Leslie J. DeGroot,
Tópico(s)Hormonal Regulation and Hypertension
ResumoA 41-yr-old female with presumed Cushing's syndrome was found to have a diurnal cortisol rhythm characterized by low values of 8:00 a.m. and consistently high values at 4:00 p.m. and midnight. Hourly sampling of plasma cortisol over 24 hr confirmed this rhythm, as did measurement of urinary free cortisols in samples collected every 6 hr over 24 hr. Hypercortisolemia was not suppressed by 2 mg of dexamethasone given every 6 hr for 24 hr. The adrenal tissue was responsive to ACTH. Iodocholesterol scanning revealed unilateral activity, and the patient's syndrome was cured by resection of an adrenal adenoma. In this patient a diurnal cortisol secretory pattern was present due to the secretory activity of the adenoma. The cause of the abnormal but persistent diurnal pattern is unknown.
Referência(s)