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Progressive multifocal leukoencephalopathy in a lung transplant recipient

2003; Elsevier BV; Volume: 22; Issue: 8 Linguagem: Inglês

10.1016/s1053-2498(02)00804-5

1557-3117

David Shitrit, Nirit Lev, Shelly I. Shiran, Gabriel Izbicki, Dov Sofer, Eldad Melamed, Mordechai R. Kramer,

Multiple Sclerosis Research Studies

Progressive multifocal leukoencephalopathy (PML) is a sub-acute, demyelinating disease of the brain caused by a human polyomavirus. We describe a patient with the onset of PML 7 months after lung transplantation. The patient was treated with immunosuppressive modulation and cidofovir, a new anti-viral therapy for PML, with stabilization of the symptoms. We also review the 4 additional reports in the literature of PML after heart and lung transplantation. Progressive multifocal leukoencephalopathy may become more prevalent as the population of heart and lung transplantation recipients increases.