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V(D)J recombination: Born to be wild

2010; Elsevier BV; Volume: 20; Issue: 4 Linguagem: Inglês

10.1016/j.semcancer.2010.06.002

ISSN

1096-3650

Autores

Dale A. Ramsden, Brett D. Weed, Yeturu V.R. Reddy,

Tópico(s)

Immune Cell Function and Interaction

Resumo

Vertebrates employ V(D)J recombination to generate diversity for an adaptive immune response. Born of a transposon, V(D)J recombination could conceivably cause more trouble than its worth. However, of the two steps required for transposon mobility (excision and integration) this particular transposon's integration step appears mostly blocked in cells. The employment of a transposon as raw material to develop adaptive immunity was thus a less-risky choice than it might have been … but is it completely risk-free?

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