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Long-term Pharmacological Therapy of Brugada Syndrome: Is J-wave Attenuation a Marker of Drug Efficacy?

2014; The Japanese Society of Internal Medicine; Volume: 53; Issue: 14 Linguagem: Inglês

10.2169/internalmedicine.53.1829

1349-7235

Kanae Hasegawa, Takashi Ashihara, Hiromi Kimura, Hikari Jo, Hideki Itoh, Takashi Yamamoto, Yoshifusa Aizawa, Minoru Horie,

Electrochemical Analysis and Applications

We herein describe two patients with Brugada syndrome in whom J-waves were successfully modified by drugs. Case 1 was a 54-year-old man who presented with repeated ventricular fibrillations (VF) and J-point elevation in the right precordial and lateral leads. After administration of cilostazol (200 mg/d), J-waves disappeared and coved-type ST-segment elevation changed to a saddleback-type for 25 months. Case 2 was a 31-year-old man who presented with a VF storm and J-point elevation in the lateral leads. After administration of quinidine (300 mg/d), J-waves and coved-type ST-segment elevation disappeared for 20 months. J-wave disappearance and coved-type ST-segment elevation were followed by VF suppression, probably due to transient outward potassium current (Ito) suppression.