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Asymmetric Self‐Replication of Chiral 1,2‐Amino Alcohols by Highly Enantioselective Autoinductive Reduction

1997; Wiley; Volume: 36; Issue: 22 Linguagem: Inglês

10.1002/anie.199724581

1521-3773

Takanori Shibata, Tomohide Takahashi, Takashi Konishi, Kenso Soai,

Analytical Chemistry and Chromatography

The product triggers the enantioselectivity. This concept is exemplified by the reduction of α-amino ketones with lithium aluminum hydride shown in Equation (1). By first modifying the reducing agent with product alcohols as chiral ligands, yields of 65–93% and ee values of 69–90% ee are obtained.