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Molecular Genetic Analysis of the ABO Blood Group System: 2. cis ‐AB Alleles

1993; Wiley; Volume: 64; Issue: 2 Linguagem: Inglês

10.1111/j.1423-0410.1993.tb02529.x

1423-0410

Fumiichiro Yamamoto, Patricia D. McNeill, Yoshihiko Kominato, Miyako Yamamoto, Sen‐itiroh Hakomori, Seiji Ishimoto, Sachiyo Nishida, Masayuki Shima, Yoshihiro Fujimura,

Erythrocyte Function and Pathophysiology

Abstract We have determined the nucleotide sequence of the coding region in the last two coding exons of ABO genes from two cis ‐AB individuals (genotype cis ‐AB/O) with no consanguinity. In this region, cis ‐AB alleles from these 2 individuals were identical to one another while different from the A 1 allele by two nucleotide substitutions. Both of these nucleotide substitutions result in amino acid substitutions. The first substitution is identical to the one previously found in the A 2 allele. The other substitution is found at the fourth position of the four amino acid substitutions which discriminate A 1 and B transferases.