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Amaranthus leucocarpusLectin Recognizes Human Naive T Cell Subpopulations

1997; Taylor & Francis; Volume: 26; Issue: 5-7 Linguagem: Inglês

10.3109/08820139709088542

1532-4311

Ricardo Lascuraín, Flor Porras, Renata Báez, Raúl Chávez, S Martínez-Cairo, Georgina Álvarez, Edgar Zenteno,

Escherichia coli research studies

Amaranthus leucocarpus lectin (ALL) is specific for GalNAc residue found in the inner core of Galβ1, 3GalNAcα1, O-Ser/Thr disaccharide (T-antigen) or GalNAcα1, O-Ser/Thr (Tn-antigen). Flow cytometric analysis using fluorescein-labeled lectin and monoclonal antibodies against human cell surface markers indicated that 5.7% of mononuclear cells from human healthy donors are recognized by ALL. These cells have the phenotype CD2+CD4+CD19− and most of the lymphocytes recognized are also CD27+, CD45RA+ and CD43+. ALL possesses mitogenic activity on lymphocytes after neuraminidase treatment. Our results indicate that the receptors recognized by ALL could be considered surface markers for naive human T lymphocyte subsets.