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Influence of glycine on morphine-induced antinociception in mice

1990; Elsevier BV; Volume: 179; Issue: 3 Linguagem: Inglês

10.1016/0014-2999(90)90169-7

1879-0712

Maria Carrara, S. Zampiron, Francesca Capolongo, L Cima, Pietro Giusti,

Neuroscience and Neuropharmacology Research

The effects of glycine on morphine-induced antinociception were investigated in mice, using a cutaneous thermal test (hot-plate), a visceral chemical test (acetylcholine writhing test), and a locomotor activity test. When glycine (200 mg/kg p.o.) and morphine (5 mg/kg s.c.) were given together during the first 30 min, glycine first antagonized the morphine-induced antinociception then this was followed by a synergistic effect. The two-phase influence of glycine on morphine-induced antinociception may be due to the interaction of glycine with different receptors.