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Immunologic mechanisms underlying bronchiolitis obliterans

2000; Lippincott Williams & Wilkins; Volume: 5; Issue: 4 Linguagem: Inglês

10.1097/00075200-200012000-00014

1531-7013

Linda Sharples, Susan Stewart,

Tracheal and airway disorders

Obliterative bronchiolitis is a histologic diagnosis of dense eosinophilic fibrous submucosal plaques in the membranous and respiratory bronchioles. It results from repeated injury, acute rejection, infection, and other inflammatory reactions. These features lead to airway epithelial damage, followed by an exaggerated healing response. There is a build-up of mesenchymal cells and collagen fibers in the lumen which results in fibrosis and partial or total obliteration of the airways. The role of immunologic factors in this process is discussed.