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The NLRP3 inflammasome, a target for therapy in diverse disease states

2010; Wiley; Volume: 40; Issue: 3 Linguagem: Inglês

10.1002/eji.200940162

1521-4141

Graham P. Cook, Sinisa Savic, Miriam Wittmann, Michael McDermott,

Kawasaki Disease and Coronary Complications

Abstract A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin‐associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.