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ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia

2013; Elsevier BV; Volume: 145; Issue: 1-3 Linguagem: Inglês

10.1016/j.schres.2013.01.011

1573-2509

Vanessa Kiyomi Ota, Ary Gadelha, Idaiane Assunção, Marcos Santoro, Denise Maria Christofolini, Fernanda T. Bellucco, Airton F. Santos-Filho, Gustavo L. Ottoni, Diogo R. Lara, Jair de Jesus Mari, Maria Isabel Melaragno, Marı́lia de Arruda Cardoso Smith, Rodrigo A. Bressan, Síntia Belangero, Andrea Parolin Jackowski,

Coronary Artery Anomalies

ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes.