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Antifungal study of the resinous exudate and of meroterpenoids isolated from Psoralea glandulosa (Fabaceae)

2012; Elsevier BV; Volume: 144; Issue: 3 Linguagem: Inglês

10.1016/j.jep.2012.10.027

1872-7573

Alejandro Madrid, Luis Espinoza, César González, Marco Mellado, Joan Villena, Rocío Santander, Viviana Silva, Iván Montenegro,

Synthesis of Organic Compounds

Psoralea glandulosa L. (Fabaceae) is a medicinal resinous shrub used in Chilean folk medicine as antiseptic in treatment of infections and skin diseases caused by bacteria and fungus.To evaluate the in vitro antifungal activity of the resin and the active components from P. glandulosa against clinical yeast isolates.Active compounds were obtained of the resinous exudate from aerial parts of P. glandulosa. Eight species of yeast were exposed to the resin and two major compounds. Minimum inhibitory concentration (MIC(80)) was determined according to the standard broth microdilution method.Bakuchiol and 3-hydroxy-bakuchiol demonstrated potent activity with the MIC(80) ranging from 4 to >16 and 0.125 to 16 μg/mL, respectively. The resin had some degree of antifungal activity.The overall results provided important information for the potential application of the 3-hydroxy-bakuchiol from P. glandulosa in the therapy of serious infection and skin diseases caused by clinical yeast.