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Pitfalls of predicting complex traits from SNPs

2013; Nature Portfolio; Volume: 14; Issue: 7 Linguagem: Inglês

10.1038/nrg3457

1471-0064

Naomi R. Wray, Jian Yang, Ben J. Hayes, Alkes L. Price, Michael E. Goddard, Peter M. Visscher,

Genetic Mapping and Diversity in Plants and Animals

The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naive implementations can lead to severe bias and misinterpretation of results.