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Artigo Revisado por pares
BIBTEX RIS

CSF neurofilament light chain is elevated in OMS (decreasing with immunotherapy) and other pediatric neuroinflammatory disorders

2013; Elsevier BV; Volume: 266; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2013.11.004

ISSN

1872-8421

Autores

Michael R. Pranzatelli, Elizabeth D. Tate, Nathan R. McGee, Steven J. Verhulst,

Tópico(s)

Tryptophan and brain disorders

Resumo

Using a panel of seven brain cell-specific biomarkers in cerebrospinal fluid (CSF), pediatric opsoclonus-myoclonus syndrome (OMS) (n=234) was compared to pediatric non-inflammatory neurological controls (n=84) and other inflammatory neurological disorders (OIND) (n=44). Only CSF NFL was elevated in untreated OMS versus controls (+83%). It was 87% higher in OIND than in OMS. On combination treatment with front-loaded ACTH, IVIg, rituximab, median CSF NFL decreased by 60% to control levels. These biochemical data suggest neuronal/axonal injury in some children with OMS without indicators of astrogliosis, and reduction on sufficient immunotherapy.

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