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Effect of Bothrops bilineata snake venom on neutrophil function

2013; Elsevier BV; Volume: 76; Linguagem: Inglês

10.1016/j.toxicon.2013.09.019

1879-3150

Sulamita da Silva Setúbal, Adriana S. Pontes, Neriane Monteiro Néry, Jessica Silva Félix Bastos, Onássis Boeri de Castro, Weverson Luciano Pires, Kayena Delaix Zaqueo, Leonardo A. Calderón, Rodrigo G. Stábeli, Andreimar M. Soares, Juliana P. Zuliani,

S100 Proteins and Annexins

The aim of the study was to evaluate the in vitro effects of Bothrops bilineata crude venom (BbV) on isolated human neutrophil function. We proved that BbV isn't toxic towards human neutrophils. During an incubation of human neutrophils with BbV hydrogen peroxide was produced. Moreover, BbV was able to stimulate neutrophil release of proinflammatory mediators such as IL-8 and IL-6 as well as PGE2 and NETs liberation. There is no data in the literature showing the effect of BbV on the production of IL-6 and IL-8 or NETs liberation by isolated human neutrophils. Taken together our results testify that BbV triggers relevant proinflammatory events in human neutrophils.