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From the Decidual Cell Internet: Trophoblast-Recognizing T Cells

1999; Oxford University Press; Volume: 60; Issue: 2 Linguagem: Inglês

10.1095/biolreprod60.2.227

1529-7268

Petra Arck, J. Dietl, David A. Clark,

Immune Cell Function and Interaction

The mammalian fetus has been perceived, paradoxically, as a successful allograft, a successful tumor, and a successful parasite. Success depends on fetal trophoblast cells, which form the interface with the mother. The maternal immune system is involved in the success of pregnancy and in its failure. The discovery that maternal γδ T cells may recognize and react to the fetal trophoblast and the definition of a vascular mechanism whereby their Th1 and Th2/3-type cytokines may abort embryos replaces confusion and debate with a new and simple clarity that enables further research.