Insoluble polystyrene-bound bis(oxazoline): batch and continuous-flow heterogeneous enantioselective glyoxylate–ene reaction
2004; Elsevier BV; Volume: 15; Issue: 20 Linguagem: Inglês
10.1016/j.tetasy.2004.08.015
ISSN1362-511X
AutoresAlessandro Mandoli, Simonetta Orlandi, Dario Pini, Piero Salvadori,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoThe use of a new, insoluble polymer-bound bis(oxazoline) ligand (IPB–box) for the copper-catalyzed heterogeneous enantioselective glyoxylate–ene reaction is described. Good activity and ee values in the range 85–95% have been obtained during five to seven recycles, either in batch mode or under flow conditions, demonstrating also the recovery and reuse of the whole catalytically active copper complex.
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