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Simultaneous production of the alpha-subunit of glycoprotein hormones and other hormones in pituitary adenomas

1988; Elsevier BV; Volume: 183; Issue: 5 Linguagem: Inglês

10.1016/s0344-0338(88)80020-7

1618-0631

G. Jautzke,

Adrenal Hormones and Disorders

The immunohistological classification of 97 pituitary adenomas revealed in 34 cases alpha-subunit (a-su) positive cells in the tumor tissue. In 15 cases a-su was the only hormone found, in 11 cases the beta-subunits of the glycoprotein hormones could also be detected (10 cases with LH/FSH and 1 case with TSH). In 8 cases a-su was found simultaneously together with other hormones of the pituitary (ACTH and a-su in 1 case, GH and a-su in 4 cases, prolactin and a-su in 2 cases, prolactin, GH and a-su in 1 case). A-su could be demonstrated to be partly simultaneously produced together with these hormones in identical cells and secretory granules. Next to prolactin, the a-su was the second most frequently occurring hormone that could be detected immunohistologically in our material.