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Targeting Epigenetic Readers in Cancer

2012; Massachusetts Medical Society; Volume: 367; Issue: 7 Linguagem: Inglês

10.1056/nejmra1112635

1533-4406

Mark A. Dawson, Tony Kouzarides, Brian J.P. Huntly,

Epigenetics and DNA Methylation

Much of gene expression is regulated by chromatin, which allows or blocks transcription. Alterations in chromatin that influence gene expression in certain cancers can be affected by drugs. Clinical testing is eagerly awaited.