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An observer‐blind, parallel‐group, randomized, multicentre clinical and microbiological study of a topical clindamycin/zinc gel and a topical clindamycin lotion in patients with mild/moderate acne

2005; Informa; Volume: 16; Issue: 4 Linguagem: Inglês

10.1080/09546630500281957

1471-1753

W.J. Cunliffe, Catherine Fernandez, R.A. Bojar, R. Kanis, Frances Mae West, The Zindaclin Clinical Study Group, W.J. Cunliffe, Catherine Fernandez, R.A. Bojar, R. Kanis, Frances Mae West, The Zindaclin Clinical Study Group,

Nail Diseases and Treatments

AbstractIntroduction: A topical acne treatment in which clindamycin phosphate equivalent to 1% clindamycin is presented in a gel formulation has received marketing authorizations in a number of EU and non‐EU countries. Clindamycin/zinc gel contains zinc acetate in a formulation that reduces systemic absorption of clindamycin through the skin. Objectives: To compare the efficacy and safety of a 1% clindamycin/zinc gel when applied to the face once daily or twice daily with a 1% clindamycin lotion applied twice daily for 16 weeks in patients with mild to moderate acne vulgaris. Methods: This was a randomized, comparative, observer‐blind, parallel‐group, multicentre study involving 246 acne patients. Results: The study demonstrated therapeutic similarity between clindamycin/zinc gel applied once and twice daily with clindamycin lotion applied twice daily. All three regimens produced a gradual and time‐dependent reduction in inflamed lesions, non‐inflamed lesions and overall grade. Side effects were similar and minimal, consisting predominantly of mild irritant dermatitis. All regimes produced a time‐related significant reduction in skin surface and follicular Propionibacterium spp. and Micrococcaceae. The emergence of resistant strains was less than 5% and was similar with all three regimes. Conclusion: The equivalent efficacy and safety of clindamycin/zinc gel either once or twice daily to clindamycin lotion twice daily has been demonstrated. It is suggested that a treatment regime of one application per day may significantly enhance compliance and thus treatment success in acne patients.KeywordsAcneclindamycinzinctopicalgellotion