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Systems biology of stem cell fate and cellular reprogramming

2009; Nature Portfolio; Volume: 10; Issue: 10 Linguagem: Inglês

10.1038/nrm2766

1471-0080

Ben D. MacArthur, Avi Ma’ayan, Ihor R. Lemischka,

3D Printing in Biomedical Research

Stem cell differentiation and the maintenance of self-renewal are intrinsically complex processes. They require the coordinated and dynamic expression of hundreds of genes and proteins, in precise response to external signalling cues. Systems biology approaches are helping to dissect this complexity. Stem cell differentiation and the maintenance of self-renewal are intrinsically complex processes requiring the coordinated dynamic expression of hundreds of genes and proteins in precise response to external signalling cues. Numerous recent reports have used both experimental and computational techniques to dissect this complexity. These reports suggest that the control of cell fate has both deterministic and stochastic elements: complex underlying regulatory networks define stable molecular 'attractor' states towards which individual cells are drawn over time, whereas stochastic fluctuations in gene and protein expression levels drive transitions between coexisting attractors, ensuring robustness at the population level.