A Genetic Study on the Streptomycin Resistance of <i>Mycobacterium tuberculosis</i>. (Report I)
1958; Genetics Society of Japan; Volume: 33; Issue: 10-11 Linguagem: Inglês
10.1266/jjg.33.341
ISSN1880-5787
AutoresMichio Tsukamura, Yo Noda, Masakuni Yamamoto, Mitsuo Hayashi,
Tópico(s)Quinazolinone synthesis and applications
ResumoA genetic study was made on the streptomycin-resistance system of Mycobacterium tuberculosis var. hominis (strains H37 Rv and Aoyama-B) and the following conculusions were obtained.Survival curves of the organism for streptomycin were discontinuous at two points, at a point between 2 and 5mcg and at another point between 20 and 50mcg under the conditions tested and it has been therefore suggestd that there are three genotypes determining streptomycin-resistance; sensitivity, lower resistance, and higher resistance.A phenomenon of interference between sensitive cells and resistant mutants as an agent suppressing the growth of resistant mutants as well as a phenomenon of phenotypic resistance have been presented.
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