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Spot urinary sodium for assessing dietary sodium restriction in cirrhotic ascites

2009; Baishideng Publishing Group; Volume: 15; Issue: 29 Linguagem: Inglês

10.3748/wjg.15.3631

2219-2840

Mohammed Abdelhamid El-Bokl, Bahaa Eldeen Senousy, Khaled Z. El-Karmouty, Inas El-Khedr Mohammed, Sherif M Mamdouh Mohammed, Sherif Sadek Shabana, Hassan Shalaby,

Electrolyte and hormonal disorders

AIM:To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics. METHODS:The study was carried on 40 patients with liver cirrhosis and ascites treated with diuretic therapy.Patients were divided into two groups according to 24-h urinary sodium.We measured spot urine Na/K ratio, Na/ Cr ratio and 24-h urinary sodium.Student's t test was used to compare the interval variables and χ 2 test to compare the nominal variables between the two groups.Receiver operator characteristic curve was used to identify the best cutoff point for Na/K and Na/Cr ratio. RESULTS:The best cutoff point for Na/K ratio was 2.5 (P < 0.001) and area under the curve (AUC) was 0.9, and for Na/Cr ratio, the best cutoff point was 35 (P < 0.001) and AUC was 0.885.Na/K ratio showed higher sensitivity and accuracy compared to Na/Cr ratio (87.5% and 87% for Na/K ratio; 81% and 85% for Na/Cr ratio, respectively).CONCLUSION: Spot urine Na/K ratio has adequate accuracy for assessment of dietary sodium restriction compared with 24-h urinary sodium in patients with liver cirrhosis and ascites.