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Antiproliferative Activity of the Main Constituents from Phyllanthus emblica

2004; Pharmaceutical Society of Japan; Volume: 27; Issue: 2 Linguagem: Inglês

10.1248/bpb.27.251

1347-5215

Ying‐Jun Zhang, Tsuneatsu Nagao, Takashi Tanaka, Chong‐Ren Yang, Hikaru Okabe, Isao Kouno,

Bioactive Compounds and Antitumor Agents

Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.