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Schutzwirkung von Ketotifen und Dinatrium cromoglicicum auf die inhalativ provozierte allergogene Bronchialobstruktion

2008; Thieme Medical Publishers (Germany); Volume: 105; Issue: 38 Linguagem: Inglês

10.1055/s-2008-1070862

1439-4413

Gerald L. Klein, R. Urbanek, H Matthys, M Hamm,

Respiratory and Cough-Related Research

The protective effect of ketotifen and disodium cromoglycate (DSCG) was evaluated by a randomised double blind cross-over study in 15 children with allergic bronchial asthma. 13 children were allergic to house dust mite (Dermatophagoides pteronyssinus), two to grass pollen. After a positive bronchial challenge test ketotifen or DSCG was given for 4 days followed by bronchial challenge with increasing allergen concentrations. Seven patients showed better allergen tolerance after ketotifen, 5 after DSCG. Protective action against late reactions was found only in 2 children after ketotifen and one child after DSCG.