Morphine Tolerance in Genetically Selected Rats Induced by Chronically Elevated Saccharin Intake
1983; American Association for the Advancement of Science; Volume: 221; Issue: 4613 Linguagem: Inglês
10.1126/science.6879185
ISSN1095-9203
AutoresIsrael Lieblich, Edna Cohen, Judith R. Ganchrow, Elliott M. Blass, Felix Bergmann,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoRats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharine solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharine intake may cause increased release and utilization of endogenous opiates.
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