Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier
2011; Elsevier BV; Volume: 19; Issue: 7 Linguagem: Inglês
10.1016/j.tim.2011.03.008
ISSN1878-4380
AutoresKyu Y. Rhee, Luiz Pedro S. de Carvalho, Ruslana Bryk, Sabine Ehrt, Joeli Marrero, Sae Woong Park, Dirk Schnappinger, Aditya Venugopal, Carl Nathan,
Tópico(s)Enzyme Structure and Function
ResumoRecent advances in liquid chromatography and mass spectrometry have enabled the highly parallel, quantitative measurement of metabolites within a cell and the ability to trace their biochemical fates. In Mycobacterium tuberculosis (Mtb), these advances have highlighted major gaps in our understanding of central carbon metabolism (CCM) that have prompted fresh interpretations of the composition and structure of its metabolic pathways and the phenotypes of Mtb strains in which CCM genes have been deleted. High-throughput screens have demonstrated that small chemical compounds can selectively inhibit some enzymes of Mtb's CCM while sparing homologs in the host. Mtb's CCM has thus emerged as a frontier for both fundamental and translational research.
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