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Validation of the MOS-HIV as a measure of health-related quality of life in persons living with HIV and liver disease

2010; Taylor & Francis; Volume: 22; Issue: 4 Linguagem: Inglês

10.1080/09540120903207292

1360-0451

Wendy A. Henderson, Elizabeth A. Schlenk, Kevin Kim, Colleen Hadigan, Angela C. Martino, Susan M. Sereika, Judith A. Erlen,

Hepatitis C virus research

Abstract Background. Management of human immunodeficiency virus (HIV) infection with potent antiretroviral medication has transformed HIV into a chronic condition and has shifted much of the burden of disease to co-morbid conditions such as liver disease (LD). LD alone has been shown to have a significant effect on one's health-related quality of life (HRQOL). Clinical evidence suggests that the growing number of persons living with HIV+LD may have a poorer HRQOL than persons with HIV without LD. To date, the widely accepted instrument to assess HRQOL, Medical Outcomes Study-HIV Health Survey (MOS-HIV), has not been evaluated for reliability and validity in a population of HIV-infected persons with LD. Methods. HRQOL was prospectively assessed using the MOS-HIV in a sample of 532 HIV-infected adults on antiretroviral therapy (n=305 HIV and n=227 HIV+LD). In addition, participants completed standardized questionnaires of sociodemographics and co-morbid conditions. Results. The psychometric properties of the MOS-HIV were supported by testing reliability and construct, convergent, discriminative, and predictive validity. The MOS-HIV discriminated between those persons living with HIV with and without LD on the basis of the physical function subscale scores (p=0.018). Conclusion. This study found the MOS-HIV valid and reliable instrument in persons with HIV+LD.