Head twitches induced by LSD and quipazine: Similarities and differences
1980; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês
10.1016/0028-3908(80)90131-8
ISSN1873-7064
AutoresJ Vetulani, Barbara Bednarczyk, Krystyna Reichenberg, Anna Rokosz,
Tópico(s)Receptor Mechanisms and Signaling
ResumoIntraperitoneal injections of LSD and quipazine produced head twitches in the rat. The dose-response curves were bell-shaped, with maxima at 50 μg/kg for LSD and 5 mg/kg for quipazine. In a single animal the responses to two consecutive treatments with the same agent were similar, and the correlation between the responsiveness to LSD and quipazine was high (r = 0.86). Head twitches induced by LSD were inhibited more strongly than those observed after quipazine by drugs impairing noradrenergic transmission and by morphine. The converse was true for a serotonin antagonist, cyproheptadine, and for morphine derivatives, particularly N-cyclopropylmethylnorazidomorphine. The results suggest an involvement of the central noradrenergic system in the response to LSD in addition to a serotonergic mechanism, and auxillary participation of one kind of opiate receptors in the action of quipazine.
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