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Coumarinylmethyl Esters for Ultrafast Release of High Concentrations of Cyclic Nucleotides upon One‐ and Two‐Photon Photolysis

2005; Wiley; Volume: 44; Issue: 48 Linguagem: Inglês

10.1002/anie.200502411

1521-3773

Volker Hagen, Brigitte Dekowski, Vasilica Nache, Reinhard Schmidt, Daniel Geißler, Dorothea Lorenz, Jenny Eichhorst, Sandro Keller, Hiroshi Kaneko, Klaus Benndorf, Burkhard Wiesner,

Radical Photochemical Reactions

Shedding light: Efficient activation of cyclic nucleoside monophosphates (cNMPs) can be achieved upon one- and two-photon flash photolysis of novel photolabile coumarinylmethyl esters of cAMP and cGMP (A=adenosine, G=guanosine) as well as their 8-bromo-substituted derivatives. The phototriggers show high solubility in water and permit space- and time-resolved investigations of the molecular mechanisms of cyclic nucleotide dependent processes. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z502411_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.