Produção Nacional
Revisado por pares
Química e farmacologia de quimioterápicos antineoplásicos derivados de plantas
2010; Brazilian Chemical Society; Volume: 33; Issue: 6 Linguagem: Inglês
10.1590/s0100-40422010000600026
ISSN1678-7064
AutoresHugo Neves Brandão, Jorge M. David, Ricardo David Couto, Jorge A. P. Nascimento, Jorge M. David,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoCHEMOTERAPEUTICAL DERIVATIVES FROM PLANTS.This review demonstrates the importance of plants as sources of molecules used in anticancer therapies.The approach is performed by relating the active molecules to their origins, details, mechanisms of action, structure-activity relationship and chemical characteristics of chemotherapeutical medicines.It was also described the development of anticancer agents from plants by the pharmaceutical industry and the difficulties to release these compounds as a trademark.These include the well known paclitaxel, docetaxel, vincristine, vinblastine, vinorelbine, vindesine, etoposide, teniposide, and other molecules that are undergoing clinical trials.
Referência(s)