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The Utility of t -Butyldimethylsilane as an Effective Silylation Reagent for the Protection of Functional Groups

1989; Oxford University Press; Volume: 62; Issue: 6 Linguagem: Inglês

10.1246/bcsj.62.2111

1348-0634

Keiji Yamamoto, Makoto Takemae,

Organoboron and organosilicon chemistry

Abstract Treatment of compounds containing functional groups, such as alcohols, amines, and carboxylic acids, with t-butyldimethylsilane in the presence of a catalytic amount of palladium on carbon is described to provide a new, convenient method for the introduction of a t-butyldimethylsilyl (TBDMS) group.