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EFFECTS OF CHRONIC ADMINISTRATION OF HUPERZINE A ON MEMORY IN GUINEA PIGS

2002; Taylor & Francis; Volume: 25; Issue: 1 Linguagem: Inglês

10.1081/dct-100108469

1525-6014

Pierre Filliat, Annie Foquin, Guy Lallement,

Pesticide Exposure and Toxicity

Effects of subchronic administration of huperzine A, a cholinesterase inhibitor, on spatial memory were studied in guinea pig. Spatial memory was appreciated by the Morris water maze test. At a dose of 0.25 microgram/h, inhibiting 36% of blood AChE and 14-20% of central AChE, no effect on spatial learning was found. At a dose of 1 microgram/h, inhibiting 20% of blood AChE and 14-20% of central AChE, no memory impairment was found, on the other hand, a memory enhancing effect, limited to the first day was shown. It thus appears that subchronic administration of huperzine A did not induce deleterious effects on spatial memory.