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Fuscoside E: A strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca

2011; Elsevier BV; Volume: 21; Issue: 19 Linguagem: Inglês

10.1016/j.bmcl.2011.07.092

1464-3405

Eduardo Reina, Carlos Puentes, Juan Rojas, Josué García, Freddy A. Ramos, Leonardo Castellanos, Diana Marcela Aragón, Luís Fernando Ospina,

Marine Biology and Environmental Chemistry

The screen of 10 soft coral extracts collected from the Colombian Caribbean Sea in the TPA-induced ear edema model allowed us to identify Eunicea fusca extract among others as an interesting source of active compounds. The new diterpene, fuscoside E (1), along with the known fuscoside B (2), fuscol (3), (+)-germacrene D (4) and a mixture of six sterols (5–10), were isolated from this soft coral. Their structures were elucidated by 1D and 2D NMR spectroscopy techniques. Fuscoside E (1) absolute stereochemistry was determined by chiroptical methods. Fuscoside E (1) and B (2) showed strong anti-inflammatory in the above mentioned bioassay. Additionally, fuscoside E (1) and the sterol mixture (5–10) presented antifouling activity against bacterial strains involved in surface colonization.