Portal de Periódicos da CAPES

P-1200 - Role of cognitive reserve on severity of illness in psychosis: a longitudinal study

2012; Cambridge University Press; Volume: 27; Linguagem: Inglês

10.1016/s0924-9338(12)75367-1

1778-3585

M. Alonso Pinedo, M. Acebo García‐Guerrero, Natalia Ojeda del Pozo, Jon García-Ormaza, Javier Peña, Rafael Segarra Echevarría, A. Ugarte Ugarte, L. Martín Otaño, Y. Ballorca Arnáiz, Miguel Fraile,

Attention Deficit Hyperactivity Disorder

The objective of the present study was to examine the predictive value of clinical and cognitive -including the cognitive reserve (CR) - variables on the severity of the patient's illness at one year of follow-up. A study was held with 45 patients with first episode psychosis (FEP) from 3 main hospitals in the Basque Country (Spain). All patients underwent cognitive, clinical, and functional assessments at baseline and at 6 months follow-up. The cognitive measures included were: the Stroop test, Vocabulary sub-test from WAIS-III, the WCST, and Trail Making Test. The clinical and functional measures included were: Positive and Negative Syndrome Scale (PANSS), Young Mania Scale, Montgomery-Asberg Depression scale, and CGI (Clinical Global Impression). Six-months follow-up data were available for 29 patients. Regression analysis was performed with the 6-month follow-up CGI measure as a dependent variable. Results showed that after controlling for CGI at baseline, -PANSS Negative Symptoms Scale (B = 0.47, p ≤ .05) and the CR measure -Vocabulary from WAIS-III- (B = 0.36, p ≤ .05) were the only two which significantly predicted severity of illness after 6 months (R2 = 0.44) and remained significant when CGI at base line was controlled in the regression analysis. The rest variables did not reach statistical significance. These findings emphasize that CR have a role on outcome in first episode psychosis, and enhance that exist a relation between cognition and clinical measures in psychosis. Basque Government, Health Department (2008111010); EITB-Maratoia (BIO 09/EM/015).