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Primary neural leprosy: systematic review

2013; Thieme Medical Publishers (Germany); Volume: 71; Issue: 6 Linguagem: Inglês

10.1590/0004-282x20130046

1678-4227

José Antônio Garbino, Wilson Marques, Jaison Antônio Barreto, Carlos Otto Heise, Márcia Rodrigues Jardim, Sérgio Luiz Gomes Antunes, Cléverson Teixeira Soares, Marcos C. Floriano, José A. C. Nery, Maria Ângela Bianconcini Trindade, Noêmia Barbosa Carvalho, Nathália Carvalho de Andrada, Amilton Antunes Barreira, Marcos Virmond,

Mycobacterium research and diagnosis

The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).