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Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction

2013; National Academy of Sciences; Volume: 110; Issue: 38 Linguagem: Inglês

10.1073/pnas.1307211110

1091-6490

Yang Hu, Ying Chen, Lexi Ding, Xuemin He, Yusuke Takahashi, Yang Gao, Wei Shen, Rui Cheng, Qian Chen, Xiaoping Qi, Michael E. Boulton, Jian‐xing Ma,

Retinoids in leukemia and cellular processes

Significance This study investigated the expression and function of peroxisome proliferator-activated receptor alpha (PPARα) in the retina and its role in diabetic retinopathy. In both type 1 and type 2 diabetes models, expression of PPARα was significantly down-regulated in the retina. PPARα knockout exacerbated diabetes-induced retinal vascular leakage and retinal inflammation, while over-expression of PPARα in the retina of diabetic rats significantly alleviated diabetic retinopathy. This study reveals that PPARα has an anti-inflammatory function in the retina. These findings also suggest that diabetes-induced down-regulation of PPARα plays an important role in diabetic retinopathy and represents a novel therapeutic target for diabetic retinopathy.