Prolonged Second Diagnostic Window for Human Immunodeficiency Virus Type 1 in a Fourth-Generation Immunoassay: Are Alternative Testing Strategies Required?
2014; American Society for Microbiology; Volume: 52; Issue: 11 Linguagem: Inglês
10.1128/jcm.01573-14
ISSN1098-660X
AutoresC. R. Robert George, Peter W. Robertson, M. Josephine Lusk, Ross Whybin, William D. Rawlinson,
Tópico(s)HIV/AIDS drug development and treatment
ResumoDiagnosis of acute HIV is done by patient history and examination and testing of RNA, proviral DNA, and serology using fourth-generation antigen/antibody detection assays. We describe an HIV-1 primary infection with a second diagnostic window of 18 to 34 days on a fourth-generation immunoassay, which would have been missed using some current algorithms. Caution must be exercised when fourth-generation HIV-1 immunoassays are interpreted in isolation, and additional testing should be considered depending on patient risk assessment.
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