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T lymphocyte subpopulations in Graves' disease: relationship with clinical conditions

1983; Oxford University Press; Volume: 102; Issue: 2 Linguagem: Inglês

10.1530/acta.0.1020213

1479-683X

Marcello Bagnasco, Giorgio Walter Canonica, Silvano Ferrini, P Biassoni, Giovanni Melioli, O Ferrini, Giulio Giordano,

Thyroid Cancer Diagnosis and Treatment

Abstract. T lymphocytes were franctionated according to their receptors for IgG (T G ) or IgM (T M ) and scored in 37 patients with Graves' disease (17 hyperthyroid and untreated, 10 euthyroid on antithyroid drugs, 10 in long-term remission after radioiodine therapy). T G percentages were very low both in untreated and in drugtreated patients. By contrast, normal T G levels were observed in patients in long-term remission. These data are consistent with the hypothesis of a defective suppressor cell activity in Graves' disease.