Solid-phase versus solution synthesis of asymmetrically disubstituted furazano[3,4-b]pyrazines
2002; Elsevier BV; Volume: 43; Issue: 27 Linguagem: Inglês
10.1016/s0040-4039(02)00913-9
ISSN1873-3581
AutoresEsther Fernández, Silvestre Garcı́a-Ochoa, S. HUSS, Araceli Mallo, José M. Bueno, Fabrizio Micheli, Alfredo Paio, Elisabetta Piga, Paola Zarantonello,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoHerein we describe a straightforward solid-phase synthesis directed towards the preparation of families of asymmetrically disubstituted furazano[3,4-b]pyrazines by stepwise displacement of the two chlorine atoms in 5,6-dichlorofurazano[3,4-b]pyrazine by nucleophiles. This synthesis has avoided selectivity problems found in solution chemistry.
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