Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Cardiovascular risk and mortality in end-stage renal disease patients undergoing dialysis: sleep study, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life: a prospective, double blind, randomized controlled clinical trial

2013; BioMed Central; Volume: 14; Issue: 1 Linguagem: Inglês

10.1186/1471-2369-14-215

1471-2369

Israel dos Reis dos Santos, Aline Roberta Danaga, Isabella de Carvalho Aguiar, Ezequiel Fernandes Oliveira, Ismael Souza Dias, Jéssica Julioti Urbano, Aline Almeida Martins, Leonardo Macário Ferraz, Nina Teixeira Fonsêca, Vítor H. Fernandes, Vinicius Alves Thomaz Fernandes, Viviane Cristina Delgado Lopes, Fernando Sergio Leitão Filho, Sérgio Roberto Nacif, Paulo de Tarso Camillo de Carvalho, Luciana Maria Malosá Sampaio, Lílian Christiane Giannasi, Salvatore Romano, Giuseppe Insalaco, Ana Karina Fachini Araújo, Humberto Dellê, Nádia Karina Guimarães de Souza, Daniel Giannella‐Neto, Luís Vicente Franco de Oliveira,

Sleep and related disorders

Abstract Background Chronic kidney disease (CKD) is one of the most serious public health problems. The increasing prevalence of CKD in developed and developing countries has led to a global epidemic. The hypothesis proposed is that patients undergoing dialysis would experience a marked negative influence on physiological variables of sleep and autonomic nervous system activity, compromising quality of life. Methods/Design A prospective, consecutive, double blind, randomized controlled clinical trial is proposed to address the effect of dialysis on sleep, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life in patients with CKD. The measurement protocol will include body weight (kg); height (cm); body mass index calculated as weight/height 2 ; circumferences (cm) of the neck, waist, and hip; heart and respiratory rates; blood pressures; Mallampati index; tonsil index; heart rate variability; maximum ventilatory pressures; negative expiratory pressure test, and polysomnography (sleep study), as well as the administration of specific questionnaires addressing sleep apnea, excessive daytime sleepiness, depression, anxiety, stress, and quality of life. Discussion CKD is a major public health problem worldwide, and its incidence has increased in part by the increased life expectancy and increasing number of cases of diabetes mellitus and hypertension. Sleep disorders are common in patients with renal insufficiency. Our hypothesis is that the weather weight gain due to volume overload observed during interdialytic period will influence the degree of collapsibility of the upper airway due to narrowing and predispose to upper airway occlusion during sleep, and to investigate the negative influences of haemodialysis in the physiological variables of sleep, and autonomic nervous system, and respiratory mechanics and thereby compromise the quality of life of patients. Trial registration The protocol for this study is registered with the Brazilian Registry of Clinical Trials (ReBEC RBR-7yhr4w and World Health Organization under Universal Trial Number UTN: U1111-1127-9390 [ http://www.ensaiosclinicos.gov.br/rg/RBR-7yhr4w/ ]).